×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASDB
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
17804836
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASDB
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
19503088
2009
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASDB
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842
2010
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASDB
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596
2012
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
LHGDN
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
17880261
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
LHGDN
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
17804836
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
LHGDN
Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population.
18625278
2008
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
LHGDN
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
18434327
2008
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
LHGDN
Association of the TRAF1/C5 locus with increased mortality, particularly from malignancy or sepsis, in patients with rheumatoid arthritis.
19116907
2009
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASCAT
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596
2012
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASCAT
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
17804836
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
GWASCAT
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842
2010
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
Biomarker
disease
CTD_human
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
18794853
2008
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
Biomarker
disease
CTD_human
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
23143596
2012
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
Biomarker
disease
BEFREE
Some of the important single nucleotide polymorphisms (SNPs) linked to RA are TRAF1 , STAT4, CTLA4, IRF5, CCR6, PTPN22, IL23R, and PADI4.
30904715
2019
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
Our results are in keeping with a previous report and suggest that the TRAF1 /C5 region is associated with risk of development of radiological erosions in IP/RA patients.
20219786
2011
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
Biomarker
disease
BEFREE
In particular, recent discoveries highlight the importance of the CD40/NF-kappaB signaling pathway in RA , based on genetic association with several genes relevant to this pathway, including CD40, TRAF1 , TNFAIP3, and REL.
20192992
2010
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
Meta-analysis showed a weak association between TRAF1 /C5 rs10818488 polymorphism and RA in all subjects (OR = 1.13, 95 % CI = 1.01–1.27, P heterogeneity < 0.001).
24234752
2014
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
We found that mutated allele A or genotypes A/A and G/A of the TRAF1 /C5 rs10818488 SNP were more common in individuals with RA than in control individuals (odds ratio [OR]=1.7, 95% confidence interval [CI]=1.35-2.15, and OR=2.22, 95% CI=1.61-3.05, respectively).
18625278
2008
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
This meta-analysis confirms that the TRAF1 -C5 rs10818488 , rs3761847 , rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
24144456
2014
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1 -C5 influences C5 mRNA levels.
26673966
2016
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
A common genetic variant at the TRAF1 -C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis .
17804836
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
GeneticVariation
disease
BEFREE
This represents the second independent study correlating rs2900180 at the TRAF1 locus with radiological severity in RA .
23242182
2013
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
Biomarker
disease
BEFREE
Based on functional data in mice, we hypothesized that the immune-related genes complement component 5 (C5) and/or TNF receptor-associated factor 1 (TRAF1 ), located on Chromosome 9q33-34, would represent relevant candidate genes for RA .
17880261
2007
×
Entrez Id:
7185
Gene Symbol:
TRAF1
TRAF1
0.500
AlteredExpression
disease
BEFREE
For the chondrocytes from OA and RA treated with 5-Aza, the mRNA expression level of TRAF1 and CTGF was highly increased (p < 0.05).
28470428
2017